Reward Processing Alters the Time Perception Networks in Patients with Major Depressive Disorder

Abstract Behavioral studies revealed that time perception is affected by the presence of a reward. Both experience and reward processing were shown to be distorted in major depressive disorder (MDD). We aimed investigate how neural correlates anticipation interact patients with MDD. Participants (17 healthy, seven MDD) performed task during fMRI scanning requires estimating speed moving rectangle which was briefly occluded. In control condition, participants attended change color tone rectangle. Half runs rewarded monetary payment per correctly done trial evaluate effect The data acquired 3T scanner analyzed repeated-measures analysis variance (ANOVA) using SPM12. activations related integration different between both groups supplementary motor area, intraparietal sulcus, thalamus, frontal eye field caudate nucleus. Increased coupling area caudate/putamen region timing found MDD more than controls. Overall, our findings suggest functional differences interaction occur via dysfunction cortico-striatal-thalamic network.